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[1] [2] Unlike phentermine's central nervous system stimulation, tirzepatide works through multiple mechanisms: it enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central pathways

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PHF3 and DIDO SPOC bind to CTD phosphorylated at serine-2, while SHARP SPOC binds to phosphorylated serine-5